Version 5.4
Bos taurus Protein: TFDP1
Summary
InnateDB Protein IDBP-686272.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TFDP1
Protein Name Transcription factor Dp-1
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000026175
InnateDB Gene IDBG-634479 (TFDP1)
Protein Structure
UniProt Annotation
Function Can stimulate E2F-dependent transcription. Binds DNA cooperatively with E2F family members through the E2 recognition site, 5'-TTTC[CG]CGC-3', found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DP2/E2F complex functions in the control of cell-cycle progression from G1 to S phase. The E2F1/DP complex appears to mediate both cell proliferation and apoptosis (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 33 interaction(s) predicted by orthology.
Predicted by orthology
Total 33 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003713 transcription coactivator activity
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0019904 protein domain specific binding
Biological Process
GO:0000278 mitotic cell cycle
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007049 cell cycle
GO:0008544 epidermis development
GO:0043276 anoikis
GO:0045893 positive regulation of transcription, DNA-templated
GO:2000278 regulation of DNA biosynthetic process
Cellular Component
GO:0005634 nucleus
GO:0005667 transcription factor complex
Protein Structure and Domains
PDB ID
InterPro IPR003316 Transcription factor E2F/dimerisation partner (TDP)
IPR014889 Transcription factor DP, C-terminal
IPR015648 Transcription factor DP
PFAM PF02319
PF08781
PRINTS
PIRSF PIRSF009404
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q17QZ4
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 534579
UniGene Bt.3383
RefSeq NP_001069497
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC118103
GenPept AAI18104

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca