Version 5.4
Bos taurus Protein: CTDNEP1
Summary
InnateDB Protein IDBP-686448.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CTDNEP1
Protein Name CTD nuclear envelope phosphatase 1
Synonyms DULLARD;
Species Bos taurus
Ensembl Protein ENSBTAP00000025896
InnateDB Gene IDBG-634663 (CTDNEP1)
Protein Structure
UniProt Annotation
Function Serine/threonine protein phosphatase forming with CNEP1R1 an active phosphatase complex that dephosphorylates and may activate LPIN1 and LPIN2. LPIN1 and LPIN2 are phosphatidate phosphatases that catalyze the conversion of phosphatidic acid to diacylglycerol and control the metabolism of fatty acids at differents levels. May indirectly modulate the lipid composition of nuclear and/or endoplasmic reticulum membranes and be required for proper nuclear membrane morphology and/or dynamics. May also indirectly regulate the production of lipid droplets and triacylglycerol. May antagonize BMP signaling (By similarity). {ECO:0000250}.
Subcellular Localization Endoplasmic reticulum membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Nucleus membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004721 phosphoprotein phosphatase activity
GO:0004722 protein serine/threonine phosphatase activity
GO:0005515 protein binding
GO:0016787 hydrolase activity
GO:0016791 phosphatase activity
Biological Process
GO:0006470 protein dephosphorylation
GO:0006998 nuclear envelope organization
GO:0007276 gamete generation
GO:0007498 mesoderm development
GO:0010867 positive regulation of triglyceride biosynthetic process
GO:0034504 protein localization to nucleus
GO:0090263 positive regulation of canonical Wnt signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005635 nuclear envelope
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0031965 nuclear membrane
GO:0071595 Nem1-Spo7 phosphatase complex
Protein Structure and Domains
PDB ID
InterPro IPR004274 NLI interacting factor
IPR011948 Dullard phosphatase domain, eukaryotic
IPR023214 HAD-like domain
PFAM PF03031
PF00702
PF08282
PF13419
PRINTS
PIRSF
SMART SM00577
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q1RMV9
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 509192
UniGene Bt.27121
RefSeq NP_001039491
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC114677
GenPept AAI14678

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca