InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: WNT16

Summary

InnateDB Protein

IDBP-686503.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

WNT16

Protein Name

protein Wnt-16 precursor

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000003825

InnateDB Gene

IDBG-634717 (WNT16)

Protein Structure

UniProt Annotation

Function

Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters (By similarity). {ECO:0000250}.

Subcellular Localization

Secreted, extracellular space, extracellular matrix {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005109	frizzled binding

Biological Process

GO:0007275	multicellular organismal development
GO:0010628	positive regulation of gene expression
GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling
GO:0016055	Wnt signaling pathway
GO:0030182	neuron differentiation
GO:0030216	keratinocyte differentiation
GO:0043616	keratinocyte proliferation
GO:0045165	cell fate commitment
GO:0046330	positive regulation of JNK cascade
GO:0046849	bone remodeling
GO:0060317	cardiac epithelial to mesenchymal transition
GO:0060548	negative regulation of cell death
GO:0090399	replicative senescence
GO:0090403	oxidative stress-induced premature senescence

Cellular Component

GO:0005576	extracellular region
GO:0005578	proteinaceous extracellular matrix
GO:0005615	extracellular space
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR005817 Wnt
IPR013304 Wnt-16 protein

PFAM

PF00110

PRINTS

PR01349
PR01895

PIRSF

SMART

SM00097

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q5E9U6

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

538627

UniGene

Bt.37171

RefSeq

NP_001014949

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC119880 BT020824

GenPept

AAI19881 AAX08841