Version 5.4
Bos taurus Protein: DYNLL1
Summary
InnateDB Protein IDBP-686578.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DYNLL1
Protein Name Dynein light chain 1, cytoplasmic
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000034172
InnateDB Gene IDBG-634795 (DYNLL1)
Protein Structure
UniProt Annotation
Function Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures (By similarity). {ECO:0000250}.Promotes transactivation functions of ESR1 and plays a role in the nuclear localization of ESR1. {ECO:0000250}.Regulates apoptotic activities of BCL2L11 by sequestering it to microtubules. Upon apoptotic stimuli the BCL2L11-DYNLL1 complex dissociates from cytoplasmic dynein and translocates to mitochondria and sequesters BCL2 thus neutralizing its antiapoptotic activity (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm, cytoskeleton {ECO:0000250}. Nucleus {ECO:0000250}. Mitochondrion {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 128 interaction(s) predicted by orthology.
Predicted by orthology
Total 128 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003774 motor activity
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006810 transport
GO:0006915 apoptotic process
GO:0007017 microtubule-based process
GO:0016032 viral process
Cellular Component
GO:0000776 kinetochore
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005856 cytoskeleton
GO:0005868 cytoplasmic dynein complex
GO:0005874 microtubule
GO:0005875 microtubule associated complex
GO:0030286 dynein complex
GO:0072686 mitotic spindle
Protein Structure and Domains
PDB ID
InterPro IPR001372 Dynein light chain, type 1/2
PFAM PF01221
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P61285
PhosphoSite PhosphoSite-
TrEMBL Q862K7
UniProt Splice Variant
Entrez Gene 789121
UniGene
RefSeq NP_001003901
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AB098977 AB099086 AY675078 BC102872 BT021030
GenPept AAI02873 AAT84371 AAX09047 BAC56467 BAC56576

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca