InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: WASL

Summary

InnateDB Protein

IDBP-686633.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

WASL

Protein Name

Neural Wiskott-Aldrich syndrome protein

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000006094

InnateDB Gene

IDBG-634828 (WASL)

Protein Structure

UniProt Annotation

Function

Involved in mitosis and cytokinesis, via its role in the regulation of actin polymerization (By similarity). Regulates actin polymerization by stimulating the actin-nucleating activity of the actin-related protein 2/3 (Arp2/3) complex. Binds to HSF1/HSTF1 and forms a complex on heat shock promoter elements (HSE) that negatively regulates HSP90 expression. {ECO:0000250, ECO:0000269PubMed:17609109}.

Subcellular Localization

Cytoplasm, cytoskeleton {ECO:0000250}. Nucleus {ECO:0000250}. Note=Preferentially localized in the cytoplasm when phosphorylated and in the nucleus when unphosphorylated. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 54 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	54 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005515	protein binding
GO:0042802	identical protein binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007015	actin filament organization
GO:0007049	cell cycle
GO:0007067	mitotic nuclear division
GO:0009617	response to bacterium
GO:0030036	actin cytoskeleton organization
GO:0032880	regulation of protein localization
GO:0034629	cellular protein complex localization
GO:0051301	cell division
GO:0051653	spindle localization