InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: METTL1

Summary

InnateDB Protein

IDBP-686673.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

METTL1

Protein Name

tRNA (guanine-N(7)-)-methyltransferase

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000022487

InnateDB Gene

IDBG-634876 (METTL1)

Protein Structure

UniProt Annotation

Function

Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. {ECO:0000255HAMAP-Rule:MF_03055}.

Subcellular Localization

Nucleus {ECO:0000255HAMAP-Rule:MF_03055}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000049	tRNA binding
GO:0003723	RNA binding
GO:0005515	protein binding
GO:0008168	methyltransferase activity
GO:0008176	tRNA (guanine-N7-)-methyltransferase activity
GO:0016740	transferase activity

Biological Process

GO:0006400	tRNA modification
GO:0008033	tRNA processing
GO:0030488	tRNA methylation
GO:0032259	methylation

Cellular Component

GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR003358 tRNA (guanine-N-7) methyltransferase
IPR029063 S-adenosyl-L-methionine-dependent methyltransferase-like

PFAM

PF02390

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q2YDF1

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

511197

UniGene

Bt.5722

RefSeq

NP_001039542

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC110252 BT029912

GenPept

AAI10253 ABM06158