Version 5.4
Bos taurus Protein: CHMP3
Summary
InnateDB Protein IDBP-686741.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CHMP3
Protein Name Charged multivesicular body protein 3
Synonyms VPS24;
Species Bos taurus
Ensembl Protein ENSBTAP00000018071
InnateDB Gene IDBG-634946 (CHMP3)
Protein Structure
UniProt Annotation
Function Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Selectively binds to phosphatidylinositol 3,5-bisphosphate PtdIns(3,5)P2 and PtdIns(3,4)P2 in preference to other phosphoinositides tested. Involved in late stages of cytokinesis. Plays a role in endosomal sorting/trafficking of EGF receptor (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm, cytosol {ECO:0000250}. Membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}. Endosome {ECO:0000250}. Late endosome membrane {ECO:0000250}. Note=Localizes to the midbody of dividing cells. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.
Predicted by orthology
Total 17 [view]
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0006810 transport
GO:0007034 vacuolar transport
GO:0015031 protein transport
Cellular Component
GO:0005737 cytoplasm
GO:0005768 endosome
GO:0005829 cytosol
GO:0016020 membrane
GO:0031902 late endosome membrane
Protein Structure and Domains
PDB ID
InterPro IPR005024 Snf7
PFAM PF03357
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q58CS7
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 507722
UniGene Bt.28232
RefSeq NP_001030223
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC114072 BT021870
GenPept AAI14073 AAX46717

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca