Version 5.4
Bos taurus Protein: OBESE
Summary
InnateDB Protein IDBP-686799.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol OBESE
Protein Name leptin precursor
Synonyms ob;
Species Bos taurus
Ensembl Protein ENSBTAP00000019853
InnateDB Gene IDBG-635003 (OBESE)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005179 hormone activity
GO:0005515 protein binding
GO:0008083 growth factor activity
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001890 placenta development
GO:0001932 regulation of protein phosphorylation
GO:0002021 response to dietary excess
GO:0006006 glucose metabolic process
GO:0006111 regulation of gluconeogenesis
GO:0006629 lipid metabolic process
GO:0006635 fatty acid beta-oxidation
GO:0007165 signal transduction
GO:0007260 tyrosine phosphorylation of STAT protein
GO:0008203 cholesterol metabolic process
GO:0008206 bile acid metabolic process
GO:0008343 adult feeding behavior
GO:0019222 regulation of metabolic process
GO:0021954 central nervous system neuron development
GO:0030073 insulin secretion
GO:0030300 regulation of intestinal cholesterol absorption
GO:0032099 negative regulation of appetite
GO:0032868 response to insulin
GO:0042307 positive regulation of protein import into nucleus
GO:0042445 hormone metabolic process
GO:0042593 glucose homeostasis
GO:0042755 eating behavior
GO:0045598 regulation of fat cell differentiation
GO:0045639 positive regulation of myeloid cell differentiation
GO:0046427 positive regulation of JAK-STAT cascade
GO:0048639 positive regulation of developmental growth
GO:0050796 regulation of insulin secretion
GO:0050810 regulation of steroid biosynthetic process
GO:0060612 adipose tissue development
GO:0070093 negative regulation of glucagon secretion
GO:2000366 positive regulation of STAT protein import into nucleus
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR000065 Leptin
IPR009079 Four-helical cytokine-like, core
PFAM PF02024
PRINTS PR00495
PIRSF PIRSF001837
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL U3GLD7
UniProt Splice Variant
Entrez Gene 280836
UniGene Bt.1939
RefSeq NP_776353
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AY044438 AY731089 DAAA02011496 HE605298 JQ711179 KC660113
GenPept AAK95823 AAU85850 AFN44373 AGT97054 CCE35542

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca