Version 5.4
Bos taurus Protein: GGCX
Summary
InnateDB Protein IDBP-686959.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GGCX
Protein Name Vitamin K-dependent gamma-carboxylase
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000027811
InnateDB Gene IDBG-635134 (GGCX)
Protein Structure
UniProt Annotation
Function Mediates the vitamin K-dependent carboxylation of glutamate residues to calcium-binding gamma-carboxyglutamate (Gla) residues with the concomitant conversion of the reduced hydroquinone form of vitamin K to vitamin K epoxide.
Subcellular Localization Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0008488 gamma-glutamyl carboxylase activity
GO:0016829 lyase activity
Biological Process
GO:0017187 peptidyl-glutamic acid carboxylation
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR007782 Vitamin K-dependent gamma-carboxylase
IPR011020 HTTM
IPR011051 RmlC-like cupin domain
PFAM PF05090
PRINTS
PIRSF
SMART SM00752
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q07175
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 281190
UniGene Bt.392
RefSeq NP_776491
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL L09726 M81593
GenPept AAA30410 AAA30425

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca