InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: DRAM2

Summary

InnateDB Protein

IDBP-686968.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DRAM2

Protein Name

DNA damage-regulated autophagy modulator protein 2

Synonyms

TMEM77;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000013037

InnateDB Gene

IDBG-635153 (DRAM2)

Protein Structure

UniProt Annotation

Function

Induces apoptotic cell death when coexpressed with DRAM1. {ECO:0000250}.

Subcellular Localization

Lysosome membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession

GO Term

Biological Process

GO:0006915	apoptotic process
GO:0030262	apoptotic nuclear changes
GO:0097194	execution phase of apoptosis

Cellular Component

GO:0005737	cytoplasm
GO:0005764	lysosome
GO:0005765	lysosomal membrane
GO:0005794	Golgi apparatus
GO:0015630	microtubule cytoskeleton
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0043231	intracellular membrane-bounded organelle

Protein Structure and Domains

PDB ID

InterPro

IPR009339 Protein of unknown function DUF998
IPR019402 Frag1/DRAM/Sfk1

PFAM

PF06197
PF10277

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q3ZC48

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

767922

UniGene

Bt.87279

RefSeq

NP_001070464

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC102918

GenPept

AAI02919