InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: PSMD2

Summary

InnateDB Protein

IDBP-687102.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PSMD2

Protein Name

26S proteasome non-ATPase regulatory subunit 2

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000007436

InnateDB Gene

IDBG-635261 (PSMD2)

Protein Structure

UniProt Annotation

Function

Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.Binds to the intracellular domain of tumor necrosis factor type 1 receptor. The binding domain of TRAP1 and TRAP2 resides outside the death domain of TNFR1 (By similarity). {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 118 interaction(s) predicted by orthology.

Predicted by orthology
Total	118 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005488	binding
GO:0005515	protein binding
GO:0030234	enzyme regulator activity

Biological Process

GO:0042176	regulation of protein catabolic process
GO:0050790	regulation of catalytic activity

Cellular Component

GO:0000502	proteasome complex
GO:0016020	membrane
GO:0022624	proteasome accessory complex
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR002015 Proteasome/cyclosome repeat
IPR016024 Armadillo-type fold
IPR016643 26S proteasome regulatory complex, non-ATPase subcomplex, Rpn1 subunit

PFAM

PF01851

PRINTS

PIRSF

PIRSF015965

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P56701

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

539784

UniGene

Bt.20443

RefSeq

NP_001094667

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC105524 BT030686

GenPept

AAI05525 ABS45002