Version 5.4
Bos taurus Protein: GNAT2
Summary
InnateDB Protein IDBP-687198.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GNAT2
Protein Name Guanine nucleotide-binding protein G(t) subunit alpha-2
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000017305
InnateDB Gene IDBG-635348 (GNAT2)
Protein Structure
UniProt Annotation
Function Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Transducin is an amplifier and one of the transducers of a visual impulse that performs the coupling between rhodopsin and cGMP-phosphodiesterase. {ECO:0000269PubMed:6586721}.
Subcellular Localization
Disease Associations
Tissue Specificity Retinal rod outer segment.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0001664 G-protein coupled receptor binding
GO:0003924 GTPase activity
GO:0004871 signal transducer activity
GO:0005525 GTP binding
GO:0008020 G-protein coupled photoreceptor activity
GO:0019001 guanyl nucleotide binding
GO:0031683 G-protein beta/gamma-subunit complex binding
GO:0046872 metal ion binding
Biological Process
GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste
GO:0006184 GTP catabolic process
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway
GO:0007601 visual perception
GO:0046549 retinal cone cell development
GO:0050896 response to stimulus
GO:0050908 detection of light stimulus involved in visual perception
Cellular Component
GO:0001750 photoreceptor outer segment
GO:0001917 photoreceptor inner segment
GO:0005834 heterotrimeric G-protein complex
GO:0042622 photoreceptor outer segment membrane
Protein Structure and Domains
PDB ID
InterPro IPR001019 Guanine nucleotide binding protein (G-protein), alpha subunit
IPR001408 G-protein alpha subunit, group I
IPR006689 Small GTPase superfamily, ARF/SAR type
IPR011025 G protein alpha subunit, helical insertion
IPR027417 P-loop containing nucleoside triphosphate hydrolase
PFAM PF00503
PF00025
PRINTS PR00318
PR00441
PR00328
PIRSF
SMART SM00275
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P04696
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 281795
UniGene Bt.472
RefSeq NP_776751
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL M11116
GenPept AAA30790

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca