Version 5.4
Bos taurus Protein: GPI
Summary
InnateDB Protein IDBP-687223.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GPI
Protein Name glucose-6-phosphate isomerase
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000008386
InnateDB Gene IDBG-635386 (GPI)
Protein Structure
UniProt Annotation
Function Besides it's role as a glycolytic enzyme, mammalian GPI can function as a tumor-secreted cytokine and an angiogenic factor (AMF) that stimulates endothelial cell motility. GPI is also a neurotrophic factor (Neuroleukin) for spinal and sensory neurons (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm. Secreted {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Predicted by orthology
Total 11 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004347 glucose-6-phosphate isomerase activity
GO:0005125 cytokine activity
GO:0016853 isomerase activity
Biological Process
GO:0001525 angiogenesis
GO:0006094 gluconeogenesis
GO:0006096 glycolytic process
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR001672 Phosphoglucose isomerase (PGI)
PFAM PF00342
PRINTS PR00662
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q3ZBD7
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 280808
UniGene Bt.49587
RefSeq NP_001035561
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AF043228 BC103416 DAAA02046903
GenPept AAB97860 AAI03417

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca