InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: UBE2H

Summary

InnateDB Protein

IDBP-687239.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

UBE2H

Protein Name

Ubiquitin-conjugating enzyme E2 H

Synonyms

E2-20K; UBCH2;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000001205

InnateDB Gene

IDBG-635401 (UBE2H)

Protein Structure

UniProt Annotation

Function

Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys- 11'- and 'Lys-48'-linked polyubiquitination. Capable, in vitro, to ubiquitinate histone H2A (By similarity). {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 61 interaction(s) predicted by orthology.

Predicted by orthology
Total	61 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016874	ligase activity
GO:0016881	acid-amino acid ligase activity

Biological Process

GO:0016567	protein ubiquitination
GO:0070936	protein K48-linked ubiquitination
GO:0070979	protein K11-linked ubiquitination

Cellular Component

Protein Structure and Domains

PDB ID

InterPro

IPR000608 Ubiquitin-conjugating enzyme, E2
IPR016135 Ubiquitin-conjugating enzyme/RWD-like

PFAM

PF00179

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q32LN1

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

539313

UniGene

Bt.4543

RefSeq

NP_001032703

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC109502

GenPept

AAI09503