InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: ATRX

Summary

InnateDB Protein

IDBP-687252.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ATRX

Protein Name

alpha thalassemia/mental retardation syndrome X-linked

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000053333

InnateDB Gene

IDBG-635337 (ATRX)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.

Predicted by orthology
Total	21 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0004386	helicase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008270	zinc ion binding
GO:0015616	DNA translocase activity
GO:0035064	methylated histone binding
GO:0042393	histone binding
GO:0070087	chromo shadow domain binding

Biological Process

GO:0006200	ATP catabolic process
GO:0006334	nucleosome assembly
GO:0006336	DNA replication-independent nucleosome assembly
GO:0006338	chromatin remodeling
GO:0007283	spermatogenesis
GO:0008152	metabolic process
GO:0010571	positive regulation of nuclear cell cycle DNA replication
GO:0030330	DNA damage response, signal transduction by p53 class mediator
GO:0030900	forebrain development
GO:0031297	replication fork processing
GO:0032206	positive regulation of telomere maintenance
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0060009	Sertoli cell development
GO:0072520	seminiferous tubule development
GO:0072711	cellular response to hydroxyurea
GO:1901581	negative regulation of telomeric RNA transcription from RNA pol II promoter

Cellular Component

GO:0000228	nuclear chromosome
GO:0000792	heterochromatin
GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0031933	telomeric heterochromatin
GO:0070603	SWI/SNF superfamily-type complex

Protein Structure and Domains

PDB ID

InterPro

IPR000330 SNF2-related
IPR001650 Helicase, C-terminal
IPR011011 Zinc finger, FYVE/PHD-type
IPR014001 Helicase, superfamily 1/2, ATP-binding domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00176
PF00271

PRINTS

PIRSF

SMART

SM00490
SM00487

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite