InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: SOD2

Summary

InnateDB Protein

IDBP-687278.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SOD2

Protein Name

Superoxide dismutase

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000008569

InnateDB Gene

IDBG-635443 (SOD2)

Protein Structure

UniProt Annotation

Function

Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.

Subcellular Localization

Mitochondrion matrix.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 44 interaction(s) predicted by orthology.

Predicted by orthology
Total	44 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004784	superoxide dismutase activity
GO:0005515	protein binding
GO:0016491	oxidoreductase activity
GO:0030145	manganese ion binding
GO:0042802	identical protein binding
GO:0046872	metal ion binding

Biological Process

GO:0000302	response to reactive oxygen species
GO:0000303	response to superoxide
GO:0001306	age-dependent response to oxidative stress
GO:0001315	age-dependent response to reactive oxygen species
GO:0001836	release of cytochrome c from mitochondria
GO:0001889	liver development
GO:0003032	detection of oxygen
GO:0003069	vasodilation by acetylcholine involved in regulation of systemic arterial blood pressure
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006749	glutathione metabolic process
GO:0006801	superoxide metabolic process
GO:0006979	response to oxidative stress
GO:0007005	mitochondrion organization
GO:0007507	heart development
GO:0007626	locomotory behavior
GO:0008217	regulation of blood pressure
GO:0008285	negative regulation of cell proliferation
GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage
GO:0008631	intrinsic apoptotic signaling pathway in response to oxidative stress
GO:0008637	apoptotic mitochondrial changes
GO:0009791	post-embryonic development
GO:0010332	response to gamma radiation
GO:0014823	response to activity
GO:0019430	removal of superoxide radicals
GO:0022904	respiratory electron transport chain
GO:0030097	hemopoiesis
GO:0032364	oxygen homeostasis
GO:0042311	vasodilation
GO:0042542	response to hydrogen peroxide
GO:0042554	superoxide anion generation
GO:0043524	negative regulation of neuron apoptotic process
GO:0045429	positive regulation of nitric oxide biosynthetic process
GO:0045599	negative regulation of fat cell differentiation
GO:0048147	negative regulation of fibroblast proliferation
GO:0048666	neuron development
GO:0048678	response to axon injury
GO:0048773	erythrophore differentiation
GO:0050790	regulation of catalytic activity
GO:0051289	protein homotetramerization
GO:0051881	regulation of mitochondrial membrane potential
GO:0055072	iron ion homeostasis
GO:0055093	response to hyperoxia
GO:0055114	oxidation-reduction process
GO:1902176	negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway