Version 5.4
Bos taurus Protein: PPME1
Summary
InnateDB Protein IDBP-687285.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PPME1
Protein Name Protein phosphatase methylesterase 1
Synonyms PME1MGC133824;
Species Bos taurus
Ensembl Protein ENSBTAP00000039548
InnateDB Gene IDBG-635447 (PPME1)
Protein Structure
UniProt Annotation
Function Demethylates proteins that have been reversibly carboxymethylated. Demethylates PPP2CB (in vitro) and PPP2CA. Binding to PPP2CA displaces the manganese ion and inactivates the enzyme (By similarity). {ECO:0000250}.
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.
Predicted by orthology
Total 15 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0016787 hydrolase activity
GO:0019903 protein phosphatase binding
GO:0051721 protein phosphatase 2A binding
GO:0051722 protein C-terminal methylesterase activity
GO:0052689 carboxylic ester hydrolase activity
Biological Process
GO:0006482 protein demethylation
Cellular Component
Protein Structure and Domains
PDB ID
InterPro IPR000073 Alpha/beta hydrolase fold-1
IPR000639 Epoxide hydrolase-like
IPR016812 Protein phosphatase methylesterase, eukaryotic
IPR029058 Alpha/Beta hydrolase fold
PFAM PF00561
PRINTS PR00111
PR00412
PIRSF PIRSF022950
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q58DN4
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 535390
UniGene Bt.51583
RefSeq NP_001069524
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC110227 BT021563
GenPept AAI10228 AAX46410

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca