InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: MRPL18

Summary

InnateDB Protein

IDBP-687304.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MRPL18

Protein Name

39S ribosomal protein L18, mitochondrial

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000001699

InnateDB Gene

IDBG-635462 (MRPL18)

Protein Structure

UniProt Annotation

Function

Together with thiosulfate sulfurtransferase (TST), acts as a mitochondrial import factor for the cytosolic 5S rRNA. The precursor form shows RNA chaperone activity; is able to fold the 5S rRNA into an import-competent conformation that is recognized by rhodanese (TST). Both the cytoplasmic and mitochondrial forms are able to bind to the helix IV-loop D in the gamma domain of the 5S rRNA (By similarity). {ECO:0000250}.

Subcellular Localization

Mitochondrion {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003723	RNA binding
GO:0003735	structural constituent of ribosome
GO:0008097	5S rRNA binding

Biological Process

GO:0006412	translation
GO:0006810	transport
GO:0035928	rRNA import into mitochondrion

Cellular Component

GO:0005615	extracellular space
GO:0005622	intracellular
GO:0005739	mitochondrion
GO:0005840	ribosome
GO:0030529	ribonucleoprotein complex

Protein Structure and Domains

PDB ID

InterPro

IPR005484 Ribosomal protein L18/L5

PFAM

PF00861

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q3ZBR7

PhosphoSite

PhosphoSite-Q3ZBR7

TrEMBL

UniProt Splice Variant

Entrez Gene

534352

UniGene

Bt.49496

RefSeq

NP_001029780

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC103149

GenPept

AAI03150