InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: CCNF

Summary

InnateDB Protein

IDBP-687332.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CCNF

Protein Name

Cyclin-F

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000034530

InnateDB Gene

IDBG-635489 (CCNF)

Protein Structure

UniProt Annotation

Function

Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication. {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000250}. Note=Localization in the centrosome is rare in S phase cells and increases in G2 cells, Localizes on both the mother and daughter centrioles. Localization to centrosomes is not dependent on CP110. Also localizes to the nucleus (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0000320	re-entry into mitotic cell cycle
GO:0001890	placenta development
GO:0007049	cell cycle
GO:0007067	mitotic nuclear division
GO:0010826	negative regulation of centrosome duplication
GO:0016567	protein ubiquitination
GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0051301	cell division
GO:0051726	regulation of cell cycle