InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: SCN1B

Summary

InnateDB Protein

IDBP-687373.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SCN1B

Protein Name

Sodium channel subunit beta-1

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000004980

InnateDB Gene

IDBG-635533 (SCN1B)

Protein Structure

UniProt Annotation

Function

Crucial in the assembly, expression, and functional modulation of the heterotrimeric complex of the sodium channel. The subunit beta-1 can modulate multiple alpha subunit isoforms from brain, skeletal muscle, and heart. Its association with neurofascin may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons (By similarity). {ECO:0000250}.

Subcellular Localization

Membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005244	voltage-gated ion channel activity
GO:0005248	voltage-gated sodium channel activity
GO:0005272	sodium channel activity
GO:0005515	protein binding
GO:0017080	sodium channel regulator activity
GO:0019871	sodium channel inhibitor activity
GO:0086006	voltage-gated sodium channel activity involved in cardiac muscle cell action potential
GO:0086062	voltage-gated sodium channel activity involved in Purkinje myocyte action potential

Biological Process

GO:0006810	transport
GO:0006811	ion transport
GO:0006814	sodium ion transport
GO:0007411	axon guidance
GO:0010765	positive regulation of sodium ion transport
GO:0010976	positive regulation of neuron projection development
GO:0019227	neuronal action potential propagation
GO:0021966	corticospinal neuron axon guidance
GO:0034765	regulation of ion transmembrane transport
GO:0035725	sodium ion transmembrane transport
GO:0040011	locomotion
GO:0051899	membrane depolarization
GO:0060048	cardiac muscle contraction
GO:0060307	regulation of ventricular cardiac muscle cell membrane repolarization
GO:0060371	regulation of atrial cardiac muscle cell membrane depolarization
GO:0061337	cardiac conduction
GO:0086002	cardiac muscle cell action potential involved in contraction
GO:0086012	membrane depolarization during cardiac muscle cell action potential
GO:0086047	membrane depolarization during Purkinje myocyte cell action potential
GO:0086091	regulation of heart rate by cardiac conduction
GO:2000649	regulation of sodium ion transmembrane transporter activity

Cellular Component

GO:0001518	voltage-gated sodium channel complex
GO:0014704	intercalated disc
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030315	T-tubule
GO:0033268	node of Ranvier
GO:0034706	sodium channel complex

Protein Structure and Domains

PDB ID

InterPro

IPR013106 Immunoglobulin V-set domain
IPR013151 Immunoglobulin

PFAM

PF07686
PF00047

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q17QN4

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

618204

UniGene

Bt.52720

RefSeq

NP_001069964

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC118258

GenPept

AAI18259