InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: LRP1

Summary

InnateDB Protein

IDBP-687543.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LRP1

Protein Name

low density lipoprotein receptor-related protein 1

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000017556

InnateDB Gene

IDBG-635332 (LRP1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 55 interaction(s) predicted by orthology.

Predicted by orthology
Total	55 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0032403	protein complex binding
GO:0034185	apolipoprotein binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006898	receptor-mediated endocytosis
GO:0008203	cholesterol metabolic process
GO:0010875	positive regulation of cholesterol efflux
GO:0014912	negative regulation of smooth muscle cell migration
GO:0030178	negative regulation of Wnt signaling pathway
GO:0032370	positive regulation of lipid transport
GO:0032374	regulation of cholesterol transport
GO:0032429	regulation of phospholipase A2 activity
GO:0032956	regulation of actin cytoskeleton organization
GO:0035909	aorta morphogenesis
GO:0043277	apoptotic cell clearance
GO:0097242	beta-amyloid clearance
GO:2000587	negative regulation of platelet-derived growth factor receptor-beta signaling pathway

Cellular Component

GO:0005765	lysosomal membrane
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0043235	receptor complex

Protein Structure and Domains

PDB ID

InterPro

IPR000033 LDLR class B repeat
IPR000742 Epidermal growth factor-like domain
IPR001881 EGF-like calcium-binding domain
IPR002172 Low-density lipoprotein (LDL) receptor class A repeat
IPR009030 Insulin-like growth factor binding protein, N-terminal

PFAM

PF00058
PF00008
PF07645
PF00057

PRINTS

PR00261

PIRSF

SMART

SM00135
SM00181
SM00179
SM00192

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt