InnateDB Protein
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IDBP-687641.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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DGAT2
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Protein Name
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diacylglycerol O-acyltransferase 2
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Synonyms
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ARAT;
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Species
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Bos taurus
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Ensembl Protein
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ENSBTAP00000001536
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InnateDB Gene
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IDBG-635771 (DGAT2)
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Protein Structure
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Function |
Essential acyltransferase that catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. Required for synthesis and storage of intracellular triglycerides. Probably plays a central role in cytosolic lipid accumulation. In liver, is primarily responsible for incorporating endogenously synthesized fatty acids into triglycerides. Functions also as an acyl-CoA retinol acyltransferase (ARAT) (By similarity). {ECO:0000250}.
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Subcellular Localization |
Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Lipid droplet {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Molecular Function |
Accession |
GO Term |
GO:0003846
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2-acylglycerol O-acyltransferase activity
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GO:0004144
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diacylglycerol O-acyltransferase activity
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GO:0016740
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transferase activity
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GO:0016746
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transferase activity, transferring acyl groups
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GO:0016747
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transferase activity, transferring acyl groups other than amino-acyl groups
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GO:0042803
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protein homodimerization activity
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GO:0050252
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retinol O-fatty-acyltransferase activity
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR007130
Diacylglycerol acyltransferase
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PFAM |
PF03982
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q70VZ8
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PhosphoSite |
PhosphoSite-
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
404129
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UniGene |
Bt.23550
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RefSeq |
NP_991362
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HUGO |
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OMIM |
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CCDS |
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HPRD |
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IMGT |
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EMBL |
AJ519787
AJ534368
AJ534369
AJ534370
AJ534371
AJ534372
AY589091
AY589092
AY589093
AY589094
AY675174
BT030532
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GenPept |
AAT02657
AAT02658
AAT02659
AAT02660
AAT78344
ABQ12972
CAD58592
CAD58968
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