Bos taurus Protein: U2AF1L4 | |||||||||||||
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Summary | |||||||||||||
InnateDB Protein | IDBP-687803.2 | ||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||
Gene Symbol | U2AF1L4 | ||||||||||||
Protein Name | Splicing factor U2AF 26 kDa subunit | ||||||||||||
Synonyms | TMEM149; | ||||||||||||
Species | Bos taurus | ||||||||||||
Ensembl Protein | ENSBTAP00000032214 | ||||||||||||
InnateDB Gene | IDBG-635920 (U2AF1L4) | ||||||||||||
Protein Structure | |||||||||||||
UniProt Annotation | |||||||||||||
Function | RNA-binding protein that function as a pre-mRNA splicing factor. Plays a critical role in both constitutive and enhancer- dependent splicing by mediating protein-protein interactions and protein-RNA interactions required for accurate 3'-splice site selection. Acts by enhancing the binding of U2AF2 to weak pyrimidine tracts. Also participates in the regulation of alternative pre-mRNA splicing. Activates exon 5 skipping of PTPRC during T-cell activation; an event reversed by GFI1. Binds to RNA at the AG dinucleotide at the 3'-splice site (By similarity). {ECO:0000250}. | ||||||||||||
Subcellular Localization | Nucleus {ECO:0000250}. Nucleus speckle {ECO:0000250}. | ||||||||||||
Disease Associations | |||||||||||||
Tissue Specificity | |||||||||||||
Comments | |||||||||||||
Interactions | |||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||
PDB ID | |||||||||||||
InterPro |
IPR000504
RNA recognition motif domain IPR000571 Zinc finger, CCCH-type IPR003954 RNA recognition motif domain, eukaryote IPR009145 U2 auxiliary factor small subunit |
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PFAM |
PF00076
PF00642 |
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PRINTS |
PR01848
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PIRSF | |||||||||||||
SMART |
SM00360
SM00356 SM00361 |
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TIGRFAMs | |||||||||||||
Post-translational Modifications | |||||||||||||
Modification | |||||||||||||
Cross-References | |||||||||||||
SwissProt | Q3T127 | ||||||||||||
PhosphoSite | PhosphoSite- | ||||||||||||
TrEMBL | |||||||||||||
UniProt Splice Variant | |||||||||||||
Entrez Gene | 615198 | ||||||||||||
UniGene | Bt.13810 | ||||||||||||
RefSeq | NP_001029950 | ||||||||||||
HUGO | |||||||||||||
OMIM | |||||||||||||
CCDS | |||||||||||||
HPRD | |||||||||||||
IMGT | |||||||||||||
EMBL | BC102151 | ||||||||||||
GenPept | AAI02152 | ||||||||||||