Version 5.4
Bos taurus Protein: PSENEN
Summary
InnateDB Protein IDBP-687807.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PSENEN
Protein Name Gamma-secretase subunit PEN-2
Synonyms PEN2;
Species Bos taurus
Ensembl Protein ENSBTAP00000024745
InnateDB Gene IDBG-635931 (PSENEN)
Protein Structure
UniProt Annotation
Function Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta- amyloid precursor protein). Probably represents the last step of maturation of gamma-secretase, facilitating endoproteolysis of presenilin and conferring gamma-secretase activity (By similarity). {ECO:0000250}.
Subcellular Localization Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Golgi apparatus, cis-Golgi network membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Predominantly located in the endoplasmic reticulum and in the cis-Golgi. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Predicted by orthology
Total 12 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0007219 Notch signaling pathway
GO:0007220 Notch receptor processing
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005794 Golgi apparatus
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR019379 Gamma-secretase aspartyl protease complex, presenilin enhancer-2 subunit
PFAM PF10251
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q5G235
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 493993
UniGene
RefSeq NP_001008669
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AY821679 AY863214 BC102375
GenPept AAI02376 AAV84001 AAW65540

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca