Version 5.4
Bos taurus Protein: CHEK2
Summary
InnateDB Protein IDBP-687926.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CHEK2
Protein Name serine/threonine-protein kinase Chk2
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000006518
InnateDB Gene IDBG-636030 (CHEK2)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 58 interaction(s) predicted by orthology.
Predicted by orthology
Total 58 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0019901 protein kinase binding
GO:0031625 ubiquitin protein ligase binding
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0000086 G2/M transition of mitotic cell cycle
GO:0006302 double-strand break repair
GO:0006355 regulation of transcription, DNA-templated
GO:0006468 protein phosphorylation
GO:0006915 apoptotic process
GO:0006974 cellular response to DNA damage stimulus
GO:0006975 DNA damage induced protein phosphorylation
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage
GO:0010332 response to gamma radiation
GO:0016310 phosphorylation
GO:0042176 regulation of protein catabolic process
GO:0042770 signal transduction in response to DNA damage
GO:0044257 cellular protein catabolic process
GO:0045893 positive regulation of transcription, DNA-templated
GO:0046777 protein autophosphorylation
GO:0050821 protein stabilization
GO:0072428 signal transduction involved in intra-S DNA damage checkpoint
GO:0090307 spindle assembly involved in mitosis
Cellular Component
GO:0000781 chromosome, telomeric region
GO:0016605 PML body
Protein Structure and Domains
PDB ID
InterPro IPR000253 Forkhead-associated (FHA) domain
IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR008984 SMAD/FHA domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain
PFAM PF00498
PF00069
PF07714
PRINTS PR00109
PIRSF
SMART SM00240
SM00220
SM00219
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL Q58DJ9
UniProt Splice Variant
Entrez Gene 518897
UniGene
RefSeq NP_001029703
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BT021598 DAAA02045588
GenPept AAX46445

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca