InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: LGR4

Summary

InnateDB Protein

IDBP-687989.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LGR4

Protein Name

leucine-rich repeat containing G protein-coupled receptor 4

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000003370

InnateDB Gene

IDBG-636061 (LGR4)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004871	signal transducer activity
GO:0004888	transmembrane signaling receptor activity
GO:0004930	G-protein coupled receptor activity
GO:0005515	protein binding

Biological Process

GO:0001649	osteoblast differentiation
GO:0002376	immune system process
GO:0007165	signal transduction
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007275	multicellular organismal development
GO:0007283	spermatogenesis
GO:0016055	Wnt signaling pathway
GO:0030154	cell differentiation
GO:0030282	bone mineralization
GO:0030539	male genitalia development
GO:0034122	negative regulation of toll-like receptor signaling pathway
GO:0035239	tube morphogenesis
GO:0045087	innate immune response
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0046849	bone remodeling
GO:0050673	epithelial cell proliferation
GO:0050710	negative regulation of cytokine secretion
GO:0061290	canonical Wnt signaling pathway involved in metanephric kidney development
GO:0072202	cell differentiation involved in metanephros development
GO:0072224	metanephric glomerulus development
GO:0072282	metanephric nephron tubule morphogenesis
GO:0090190	positive regulation of branching involved in ureteric bud morphogenesis
GO:0090263	positive regulation of canonical Wnt signaling pathway

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR000372 Leucine-rich repeat-containing N-terminal
IPR001611 Leucine-rich repeat
IPR002131 Glycoprotein hormone receptor family
IPR003591 Leucine-rich repeat, typical subtype
IPR017452 GPCR, rhodopsin-like, 7TM

PFAM

PF00001
PF01462
PF00560
PF13504
PF13855

PRINTS

PR00237
PR00373

PIRSF

SMART

SM00013
SM00369

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt