Version 5.4
| Bos taurus Protein: KLHL12 | |||||||||||||||
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| Summary | |||||||||||||||
| InnateDB Protein | IDBP-688010.3 | ||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||
| Gene Symbol | KLHL12 | ||||||||||||||
| Protein Name | kelch-like protein 12 | ||||||||||||||
| Synonyms | |||||||||||||||
| Species | Bos taurus | ||||||||||||||
| Ensembl Protein | ENSBTAP00000040061 | ||||||||||||||
| InnateDB Gene | IDBG-636078 (KLHL12) | ||||||||||||||
| Protein Structure |
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| UniProt Annotation | |||||||||||||||
| Function | Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of Wnt signaling pathway and ER-Golgi transport. The BCR(KLHL12) complex is involved in ER-Golgi transport by regulating the size of COPII coats, thereby playing a key role in collagen export, which is required for embryonic stem (ES) cells division: BCR(KLHL12) acts by mediating monoubiquitination of SEC31 (SEC31A or SEC31B). As part of the BCR(KLHL12) complex, also acts as a negative regulator of the Wnt signaling pathway by mediating ubiquitination and subsequent proteolysis of DVL3 (By similarity). {ECO:0000250}. | ||||||||||||||
| Subcellular Localization | Cytoplasmic vesicle, COPII-coated vesicle {ECO:0000250}. | ||||||||||||||
| Disease Associations | |||||||||||||||
| Tissue Specificity | |||||||||||||||
| Comments | |||||||||||||||
| Interactions | |||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 26 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Protein Structure and Domains | |||||||||||||||
| PDB ID | |||||||||||||||
| InterPro |
IPR000210
BTB/POZ-like IPR006652 Kelch repeat type 1 IPR011333 BTB/POZ fold IPR011705 BTB/Kelch-associated IPR013069 BTB/POZ IPR017096 Kelch-like protein, gigaxonin type |
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| PFAM |
PF01344
PF07707 PF00651 |
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| PRINTS | |||||||||||||||
| PIRSF |
PIRSF037037
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| SMART |
SM00225
SM00612 SM00875 |
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| TIGRFAMs | |||||||||||||||
| Post-translational Modifications | |||||||||||||||
| Modification | |||||||||||||||
| Cross-References | |||||||||||||||
| SwissProt | E1B932 | ||||||||||||||
| PhosphoSite | PhosphoSite- | ||||||||||||||
| TrEMBL | |||||||||||||||
| UniProt Splice Variant | |||||||||||||||
| Entrez Gene | 768068 | ||||||||||||||
| UniGene | |||||||||||||||
| RefSeq | NP_001070593 | ||||||||||||||
| HUGO | |||||||||||||||
| OMIM | |||||||||||||||
| CCDS | |||||||||||||||
| HPRD | |||||||||||||||
| IMGT | |||||||||||||||
| EMBL | DAAA02043311 | ||||||||||||||
| GenPept | |||||||||||||||