InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: CREBBP

Summary

InnateDB Protein

IDBP-688035.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CREBBP

Protein Name

CREB-binding protein

Synonyms

hmm291030;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000005092

InnateDB Gene

IDBG-636113 (CREBBP)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 306 interaction(s) predicted by orthology.

Predicted by orthology
Total	306 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000987	core promoter proximal region sequence-specific DNA binding
GO:0001078	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0001085	RNA polymerase II transcription factor binding
GO:0001191	RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription
GO:0002039	p53 binding
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003712	transcription cofactor activity
GO:0003713	transcription coactivator activity
GO:0004402	histone acetyltransferase activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0008270	zinc ion binding
GO:0016407	acetyltransferase activity
GO:0016740	transferase activity
GO:0016746	transferase activity, transferring acyl groups
GO:0043426	MRF binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006355	regulation of transcription, DNA-templated
GO:0016573	histone acetylation
GO:0018076	N-terminal peptidyl-lysine acetylation
GO:0030718	germ-line stem cell maintenance
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter

Cellular Component

GO:0000123	histone acetyltransferase complex
GO:0000790	nuclear chromatin
GO:0000940	condensed chromosome outer kinetochore
GO:0005634	nucleus
GO:0005667	transcription factor complex
GO:0005737	cytoplasm
GO:0016604	nuclear body

Protein Structure and Domains

PDB ID

InterPro

IPR000197 Zinc finger, TAZ-type
IPR000433 Zinc finger, ZZ-type
IPR001487 Bromodomain
IPR003101 Coactivator CBP, KIX domain
IPR009110 Nuclear receptor coactivator, interlocking
IPR010303 Domain of unknown function DUF902, CREBbp
IPR011011 Zinc finger, FYVE/PHD-type
IPR013178 Histone H3-K56 acetyltransferase, RTT109
IPR014744 Nuclear receptor coactivator, CREB-bp-like, interlocking

PFAM

PF02135
PF00569
PF00439
PF02172
PF06001
PF08214
PF09030

PRINTS

PR00503

PIRSF

SMART

SM00551
SM00291
SM00297

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

F1MD32

UniProt Splice Variant

Entrez Gene

505453

UniGene

Bt.9058

RefSeq

NP_001157494

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

DAAA02057328 GJ062847

GenPept

DAA15549