InnateDB Protein
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IDBP-688074.2
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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NCEH1
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Protein Name
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Neutral cholesterol ester hydrolase 1
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Synonyms
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AADACL1;
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Species
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Bos taurus
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Ensembl Protein
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ENSBTAP00000026745
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InnateDB Gene
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IDBG-636173 (NCEH1)
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Protein Structure
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Function |
Hydrolyzes 2-acetyl monoalkylglycerol ether, the penultimate precursor of the pathway for de novo synthesis of platelet-activating factor. May be responsible for cholesterol ester hydrolysis in macrophages. Also involved in organ detoxification by hydrolyzing exogenous organophosphorus compounds (By similarity). {ECO:0000250}.
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Subcellular Localization |
Membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. Microsome {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR013094
Alpha/beta hydrolase fold-3
IPR017157
Arylacetamide deacetylase
IPR029058
Alpha/Beta hydrolase fold
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PFAM |
PF07859
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PRINTS |
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PIRSF |
PIRSF037251
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q1JQE6
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PhosphoSite |
PhosphoSite-
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
534212
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UniGene |
Bt.64890
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RefSeq |
NP_001116506
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HUGO |
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OMIM |
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CCDS |
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HPRD |
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IMGT |
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EMBL |
BC115993
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GenPept |
AAI15994
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