InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: NTRK2

Summary

InnateDB Protein

IDBP-688120.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NTRK2

Protein Name

BDNF/NT-3 growth factors receptor

Synonyms

Trk-B; TrkB;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000053704

InnateDB Gene

IDBG-636149 (NTRK2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 27 interaction(s) predicted by orthology.

Predicted by orthology
Total	27 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0004714	transmembrane receptor protein tyrosine kinase activity
GO:0005030	neurotrophin receptor activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016301	kinase activity
GO:0016740	transferase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0048403	brain-derived neurotrophic factor binding
GO:0060175	brain-derived neurotrophic factor-activated receptor activity

Biological Process

GO:0001570	vasculogenesis
GO:0001764	neuron migration
GO:0006468	protein phosphorylation
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007528	neuromuscular junction development
GO:0007612	learning
GO:0007623	circadian rhythm
GO:0007631	feeding behavior
GO:0010628	positive regulation of gene expression
GO:0010976	positive regulation of neuron projection development
GO:0014047	glutamate secretion
GO:0016310	phosphorylation
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0019222	regulation of metabolic process
GO:0021954	central nervous system neuron development
GO:0021987	cerebral cortex development
GO:0030182	neuron differentiation
GO:0031547	brain-derived neurotrophic factor receptor signaling pathway
GO:0032314	regulation of Rac GTPase activity
GO:0035584	calcium-mediated signaling using intracellular calcium source
GO:0038179	neurotrophin signaling pathway
GO:0042490	mechanoreceptor differentiation
GO:0046548	retinal rod cell development
GO:0048709	oligodendrocyte differentiation
GO:0048935	peripheral nervous system neuron development
GO:0051896	regulation of protein kinase B signaling
GO:0060291	long-term synaptic potentiation
GO:2000811	negative regulation of anoikis

Cellular Component

GO:0005768	endosome
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0043195	terminal bouton
GO:0043235	receptor complex
GO:0045211	postsynaptic membrane
GO:0097481	neuronal postsynaptic density

Protein Structure and Domains

PDB ID

InterPro

IPR000372 Leucine-rich repeat-containing N-terminal
IPR000483 Cysteine-rich flanking region, C-terminal
IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR003598 Immunoglobulin subtype 2
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR011009 Protein kinase-like domain
IPR013098 Immunoglobulin I-set
IPR020455 Tyrosine-protein kinase, neurotrophic receptor, type 2
IPR020635 Tyrosine-protein kinase, catalytic domain
IPR020777 Tyrosine-protein kinase, neurotrophic receptor

PFAM

PF01462
PF01463
PF00069
PF07714
PF07679

PRINTS

PR00109
PR01941
PR01939

PIRSF

SMART

SM00013
SM00082
SM00220
SM00408
SM00409
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt