InnateDB Protein
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IDBP-688138.2
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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TBCB
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Protein Name
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Tubulin-folding cofactor B
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Synonyms
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CKAP1;
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Species
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Bos taurus
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Ensembl Protein
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ENSBTAP00000019973
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InnateDB Gene
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IDBG-636228 (TBCB)
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Protein Structure
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Function |
Binds to alpha-tubulin folding intermediates after their interaction with cytosolic chaperonin in the pathway leading from newly synthesized tubulin to properly folded heterodimer. Involved in regulation of tubulin heterodimer dissociation. May function as a negative regulator of axonal growth (By similarity). {ECO:0000250}.
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Subcellular Localization |
Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Colocalizes with microtubules. In differentiated neurons, located in the cytoplasm. In differentiating neurons, accumulates at the growth cone (By similarity). {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
3 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000938
CAP Gly-rich domain
IPR029071
Ubiquitin-related domain
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PFAM |
PF01302
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PRINTS |
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PIRSF |
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SMART |
SM01052
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TIGRFAMs |
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Modification |
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SwissProt |
Q5E951
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PhosphoSite |
PhosphoSite-
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
530447
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UniGene |
Bt.55460
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RefSeq |
NP_001014939
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HUGO |
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OMIM |
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CCDS |
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HPRD |
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IMGT |
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EMBL |
BC102571
BT021069
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GenPept |
AAI02572
AAX09086
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