InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: GLYR1

Summary

InnateDB Protein

IDBP-688349.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GLYR1

Protein Name

Putative oxidoreductase GLYR1

Synonyms

N-PAC;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000002268

InnateDB Gene

IDBG-636411 (GLYR1)

Protein Structure

UniProt Annotation

Function

May have oxidoreductase activity. Regulates p38 MAP kinase activity by mediating stress activation of p38alpha/MAPK14 and specifically regulating MAPK14 signaling. Indirectly promotes phosphorylation of MAPK14 and activation of ATF2. The phosphorylation of MAPK14 requires upstream activity of MAP2K4 and MAP2K6. Recruited on chromatin, recognizes and binds trimethylated 'Lys-36' of histone H3 (H3K36me3) (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0004616	phosphogluconate dehydrogenase (decarboxylating) activity
GO:0016491	oxidoreductase activity
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0035064	methylated histone binding
GO:0050662	coenzyme binding
GO:0051287	NAD binding

Biological Process

GO:0006098	pentose-phosphate shunt
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005794	Golgi apparatus

Protein Structure and Domains

PDB ID

InterPro

IPR000313 PWWP domain
IPR006115 6-phosphogluconate dehydrogenase, NADP-binding
IPR008927 6-phosphogluconate dehydrogenase, C-terminal-like
IPR028939 Pyrroline-5-carboxylate reductase, catalytic, N-terminal

PFAM

PF00855
PF03446
PF03807

PRINTS

PIRSF

SMART

SM00293

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

A4FUF0