Version 5.4
Bos taurus Protein: FBXO3
Summary
InnateDB Protein IDBP-688359.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FBXO3
Protein Name F-box only protein 3
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000013287
InnateDB Gene IDBG-636434 (FBXO3)
Protein Structure
UniProt Annotation
Function Substrate recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex. Mediates the ubiquitination of HIPK2 and probably that of EP300, leading to rapid degradation by the proteasome. In the presence of PML, HIPK2 ubiquitination still occurs, but degradation is prevented. PML, HIPK2 and FBXO3 may act synergically to activate p53/TP53- dependent transactivation (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000250}. Note=Colocalizes with PML at the peripheries of nuclear bodies. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.
Predicted by orthology
Total 16 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006508 proteolysis
GO:0016567 protein ubiquitination
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR001810 F-box domain
IPR007474 ApaG domain
IPR018958 SMI1/KNR4 like domain
PFAM PF00646
PF12937
PF13013
PF04379
PF09346
PRINTS
PIRSF
SMART SM00256
SM00860
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt A6H7H7
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 534287
UniGene Bt.91417
RefSeq NP_001092532
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC146250
GenPept AAI46251

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca