Version 5.4
Bos taurus Protein: RDH5
Summary
InnateDB Protein IDBP-688415.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RDH5
Protein Name 11-cis retinol dehydrogenase
Synonyms 9cRDH;
Species Bos taurus
Ensembl Protein ENSBTAP00000056512
InnateDB Gene IDBG-636491 (RDH5)
Protein Structure
UniProt Annotation
Function Stereospecific 11-cis retinol dehydrogenase, which catalyzes the final step in the biosynthesis of 11-cis retinaldehyde, the universal chromophore of visual pigments. Also able to oxidize 9-cis-retinol and 13-cis-retinol, but not all- trans-retinol. Active in the presence of NAD as cofactor but not in the presence of NADP. {ECO:0000269PubMed:7544779, ECO:0000269PubMed:7836368, ECO:0000269PubMed:9654122}.
Subcellular Localization Endoplasmic reticulum lumen {ECO:0000250}. Membrane {ECO:0000269PubMed:7836368}; Peripheral membrane protein {ECO:0000269PubMed:7836368}.
Disease Associations
Tissue Specificity Expressed in retinal pigment epithelial cells. Expression detected in smooth muscle cells of the small arteries in liver, kidney, small intestine and heart, and in small intestine also in the muscularis mucosae and muscularis propria (at protein level; PubMed:9654122). Expressed in eye in retinal pigment epithelium but not in lens capsule, iris, retina, cornea epithelium and ciliary body. Not detected in adrenal gland, lung, testis, brain, muscle and spleen. Not detected in liver, kidney, heart and small intestine (PubMed:7544779 and PubMed:7836368). {ECO:0000269PubMed:7544779, ECO:0000269PubMed:7836368, ECO:0000269PubMed:9654122}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0016491 oxidoreductase activity
Biological Process
GO:0007601 visual perception
GO:0008152 metabolic process
GO:0042572 retinol metabolic process
GO:0050896 response to stimulus
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005788 endoplasmic reticulum lumen
GO:0016020 membrane
Protein Structure and Domains
PDB ID
InterPro IPR002198 Short-chain dehydrogenase/reductase SDR
IPR002347 Glucose/ribitol dehydrogenase
IPR003560 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase
PFAM PF00106
PRINTS PR00080
PR00081
PR01397
PIRSF PIRSF000126
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q27979
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 281448
UniGene Bt.4598
RefSeq NP_776591
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02013541 L36533 X82262
GenPept AAA80694 CAA57715

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca