InnateDB Protein
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IDBP-688421.2
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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BLOC1S1
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Protein Name
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Biogenesis of lysosome-related organelles complex 1 subunit 1
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Synonyms
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Species
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Bos taurus
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Ensembl Protein
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ENSBTAP00000015810
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InnateDB Gene
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IDBG-636497 (BLOC1S1)
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Protein Structure
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Function |
Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. May negatively regulate aerobic respiration through mitochondrial protein lysine-acetylation. May counteract the action of the deacetylase SIRT3 by acetylating and regulating proteins of the mitochondrial respiratory chain including ATP5A1 and NDUFA9 (By similarity). {ECO:0000250}.
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Subcellular Localization |
Mitochondrion intermembrane space. Mitochondrion matrix {ECO:0000250}. Cytoplasm, cytosol {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
15 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR009395
GCN5-like 1
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PFAM |
PF06320
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q2NKW0
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PhosphoSite |
PhosphoSite-
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
615149
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UniGene |
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RefSeq |
NP_001069830
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HUGO |
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OMIM |
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CCDS |
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HPRD |
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IMGT |
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EMBL |
BC111605
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GenPept |
AAI11606
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