InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: PRKCI

Summary

InnateDB Protein

IDBP-688490.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PRKCI

Protein Name

protein kinase C, iota

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000053326

InnateDB Gene

IDBG-636461 (PRKCI)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 69 interaction(s) predicted by orthology.

Predicted by orthology
Total	69 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0005543	phospholipid binding
GO:0008270	zinc ion binding
GO:0016301	kinase activity
GO:0016740	transferase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0046872	metal ion binding

Biological Process

GO:0006468	protein phosphorylation
GO:0007015	actin filament organization
GO:0010976	positive regulation of neuron projection development
GO:0016310	phosphorylation
GO:0034351	negative regulation of glial cell apoptotic process
GO:0035089	establishment of apical/basal cell polarity
GO:0035556	intracellular signal transduction
GO:0042462	eye photoreceptor cell development
GO:0043524	negative regulation of neuron apoptotic process
GO:0045216	cell-cell junction organization
GO:0046326	positive regulation of glucose import
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:0060252	positive regulation of glial cell proliferation
GO:0090004	positive regulation of establishment of protein localization to plasma membrane
GO:2000353	positive regulation of endothelial cell apoptotic process

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0015630	microtubule cytoskeleton
GO:0016324	apical plasma membrane
GO:0043220	Schmidt-Lanterman incisure
GO:0045171	intercellular bridge
GO:0045177	apical part of cell
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000270 Phox/Bem1p
IPR000719 Protein kinase domain
IPR000961 AGC-kinase, C-terminal
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR017892 Protein kinase, C-terminal
IPR020454 Diacylglycerol/phorbol-ester binding
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00564
PF00069
PF07714
PF00130
PF00433

PRINTS

PR00109
PR00008

PIRSF

SMART

SM00666
SM00133
SM00109
SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt