Version 5.4
Bos taurus Protein: UXT
Summary
InnateDB Protein IDBP-688723.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol UXT
Protein Name Protein UXT
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000030041
InnateDB Gene IDBG-636768 (UXT)
Protein Structure
UniProt Annotation
Function Involved in gene transcription regulation. Acts in concert with the corepressor URI1 to regulate androgen receptor (AR) transcription. AR N-terminus-associated coactivator which may play a role in facilitating receptor-induced transcriptional activation. Potential component of mitochondrial-associated LRPPRC, a multidomain organizer that potentially integrates mitochondria and the microtubular cytoskeleton with chromosome remodeling. Increasing concentrations of UXT contributes to progressive aggregation of mitochondria and cell death potentially through its association with LRPPRC. May be a nuclear chaperone that promotes formation of the NF-kappa-B enhanceosome and which is essential for its nuclear function. Suppresses cell transformation and it might mediate this function by interaction and inhibition of the biological activity of cell proliferation and survival stimulatory factors like MECOM. Together with URI1, associates with chromatin to the NKX3-1 promoter region (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Nucleus {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.
Predicted by orthology
Total 18 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001106 RNA polymerase II transcription corepressor activity
GO:0003682 chromatin binding
GO:0005515 protein binding
GO:0048487 beta-tubulin binding
GO:0051082 unfolded protein binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0000226 microtubule cytoskeleton organization
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006457 protein folding
GO:0051297 centrosome organization
Cellular Component
GO:0000930 gamma-tubulin complex
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005815 microtubule organizing center
GO:0005856 cytoskeleton
GO:0016272 prefoldin complex
Protein Structure and Domains
PDB ID
InterPro IPR003994 Prefoldin-related, ubiquitously expressed transcript
IPR004127 Prefoldin alpha-like
IPR009053 Prefoldin
PFAM PF02996
PRINTS PR01502
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q32P97
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 525680
UniGene Bt.62980
RefSeq NP_001032548
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC108205
GenPept AAI08206

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca