Version 5.4
Bos taurus Protein: GATA1
Summary
InnateDB Protein IDBP-688848.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GATA1
Protein Name GATA binding protein 1 (globin transcription factor 1)
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000004135
InnateDB Gene IDBG-636875 (GATA1)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 72 interaction(s) predicted by orthology.
Predicted by orthology
Total 72 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000976 transcription regulatory region sequence-specific DNA binding
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001078 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0001085 RNA polymerase II transcription factor binding
GO:0001158 enhancer sequence-specific DNA binding
GO:0002039 p53 binding
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0008301 DNA binding, bending
GO:0031490 chromatin DNA binding
GO:0043565 sequence-specific DNA binding
GO:0070742 C2H2 zinc finger domain binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001701 in utero embryonic development
GO:0006355 regulation of transcription, DNA-templated
GO:0006366 transcription from RNA polymerase II promoter
GO:0007267 cell-cell signaling
GO:0008285 negative regulation of cell proliferation
GO:0008584 male gonad development
GO:0010559 regulation of glycoprotein biosynthetic process
GO:0010724 regulation of definitive erythrocyte differentiation
GO:0030099 myeloid cell differentiation
GO:0030218 erythrocyte differentiation
GO:0030219 megakaryocyte differentiation
GO:0030220 platelet formation
GO:0030221 basophil differentiation
GO:0030222 eosinophil differentiation
GO:0030502 negative regulation of bone mineralization
GO:0033690 positive regulation of osteoblast proliferation
GO:0035162 embryonic hemopoiesis
GO:0035854 eosinophil fate commitment
GO:0043066 negative regulation of apoptotic process
GO:0045648 positive regulation of erythrocyte differentiation
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048468 cell development
GO:0048821 erythrocyte development
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0070527 platelet aggregation
GO:0071733 transcriptional activation by promoter-enhancer looping
GO:0097028 dendritic cell differentiation
GO:0097067 cellular response to thyroid hormone stimulus
GO:2000678 negative regulation of transcription regulatory region DNA binding
GO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
Cellular Component
GO:0005634 nucleus
GO:0005667 transcription factor complex
GO:0017053 transcriptional repressor complex
Protein Structure and Domains
PDB ID
InterPro IPR000679 Zinc finger, GATA-type
IPR016374 Transcription factor, GATA-1/2/3
PFAM PF00320
PRINTS PR00619
PIRSF PIRSF003027
SMART SM00401
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL E1BI59
UniProt Splice Variant
Entrez Gene 516066
UniGene Bt.24556
RefSeq NP_001193169
HUGO HGNC:4170
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02073074
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca