Version 5.4
Bos taurus Protein: CISD1
Summary
InnateDB Protein IDBP-688971.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CISD1
Protein Name CDGSH iron-sulfur domain-containing protein 1
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000004739
InnateDB Gene IDBG-636995 (CISD1)
Protein Structure
UniProt Annotation
Function Plays a key role in regulating maximal capacity for electron transport and oxidative phosphorylation. May be involved in Fe-S cluster shuttling and/or in redox reactions (By similarity). {ECO:0000250}.
Subcellular Localization Mitochondrion outer membrane {ECO:0000269PubMed:14570702}; Single-pass type III membrane protein {ECO:0000269PubMed:14570702}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0046872 metal ion binding
GO:0051536 iron-sulfur cluster binding
GO:0051537 2 iron, 2 sulfur cluster binding
Biological Process
GO:0043457 regulation of cellular respiration
Cellular Component
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0043231 intracellular membrane-bounded organelle
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR006622 Iron sulphur-containing domain, CDGSH-type, subfamily
IPR018967 Iron sulphur-containing domain, CDGSH-type
IPR019610 Iron sulphur domain-containing, mitoNEET, N-terminal
PFAM PF09360
PF10660
PRINTS
PIRSF
SMART SM00704
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q3ZBU2
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 531444
UniGene
RefSeq NP_001029229
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC103105
GenPept AAI03106

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca