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InnateDB Protein
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IDBP-689015.2
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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TFE3
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Protein Name
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Transcription factor E3
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Synonyms
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Species
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Bos taurus
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Ensembl Protein
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ENSBTAP00000011237
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InnateDB Gene
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IDBG-637031 (TFE3)
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Protein Structure
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| Function |
Transcription factor that specifically recognizes and binds E-box sequences (5'-CANNTG-3'). Efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFEB or MITF. In association with TFEB, activates the expression of CD40L in T-cells, thereby playing a role in T- cell-dependent antibody responses in activated CD4(+) T-cells and thymus-dependent humoral immunity. Specifically recognizes the MUE3 box, a subset of E-boxes, present in the immunoglobulin enhancer. It also binds very well to a USF/MLTF site (By similarity). {ECO:0000250}.
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| Subcellular Localization |
Nucleus {ECO:0000255PROSITE- ProRule:PRU00981}.
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| Disease Associations |
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| Tissue Specificity |
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| Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 43 interaction(s) predicted by orthology.
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| Predicted by orthology |
| Total |
43 [view]
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Molecular Function |
| Accession |
GO Term |
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GO:0003677
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DNA binding
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GO:0003700
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sequence-specific DNA binding transcription factor activity
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GO:0044212
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transcription regulatory region DNA binding
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GO:0046983
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protein dimerization activity
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| Biological Process |
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GO:0002376
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immune system process
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GO:0006351
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transcription, DNA-templated
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GO:0006355
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regulation of transcription, DNA-templated
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GO:0006959
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humoral immune response
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GO:0045670
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regulation of osteoclast differentiation
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GO:0045785
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positive regulation of cell adhesion
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GO:0045893
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positive regulation of transcription, DNA-templated
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GO:0045944
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positive regulation of transcription from RNA polymerase II promoter
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| Cellular Component |
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| PDB ID |
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| InterPro |
IPR011598
Myc-type, basic helix-loop-helix (bHLH) domain
IPR021802
Basic helix-loop-helix leucine zipper transcrition factor MiT/TFE
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| PFAM |
PF00010
PF11851
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| PRINTS |
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| PIRSF |
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| SMART |
SM00353
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| TIGRFAMs |
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| Modification |
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| SwissProt |
Q05B92
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| PhosphoSite |
PhosphoSite-
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| TrEMBL |
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| UniProt Splice Variant |
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| Entrez Gene |
520800
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| UniGene |
Bt.20221
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| RefSeq |
NP_001069279
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| HUGO |
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| OMIM |
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| CCDS |
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| HPRD |
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| IMGT |
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| EMBL |
BC122581
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| GenPept |
AAI22582
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Version 5.4