Version 5.4
Bos taurus Protein: PFKFB3
Summary
InnateDB Protein IDBP-689031.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PFKFB3
Protein Name 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000048148
InnateDB Gene IDBG-637046 (PFKFB3)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0003873 6-phosphofructo-2-kinase activity
GO:0004331 fructose-2,6-bisphosphate 2-phosphatase activity
GO:0005524 ATP binding
GO:0016301 kinase activity
Biological Process
GO:0006000 fructose metabolic process
GO:0006003 fructose 2,6-bisphosphate metabolic process
GO:0008152 metabolic process
GO:0016310 phosphorylation
GO:0016311 dephosphorylation
GO:0046835 carbohydrate phosphorylation
Cellular Component
Protein Structure and Domains
PDB ID
InterPro IPR003094 Fructose-2,6-bisphosphatase
IPR013078 Histidine phosphatase superfamily, clade-1
IPR013079 6-phosphofructo-2-kinase
IPR013641 Chromatin associated protein KTI12
IPR016260 Bifunctional 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphate 2-phosphatase
IPR027417 P-loop containing nucleoside triphosphate hydrolase
IPR029033 Histidine phosphatase superfamily
PFAM PF00300
PF01591
PF08433
PRINTS PR00991
PIRSF PIRSF000709
SMART SM00855
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL A0JN55
UniProt Splice Variant
Entrez Gene 407183
UniGene Bt.12314
RefSeq NP_001071305
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC126523 DAAA02035344
GenPept AAI26524

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca