Version 5.4
| Bos taurus Protein: IGF1 | |||||||||
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| Summary | |||||||||
| InnateDB Protein | IDBP-689150.2 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | IGF1 | ||||||||
| Protein Name | Insulin-like growth factor I | ||||||||
| Synonyms | IGF-1; IGF-I; | ||||||||
| Species | Bos taurus | ||||||||
| Ensembl Protein | ENSBTAP00000014713 | ||||||||
| InnateDB Gene | IDBG-637164 (IGF1) | ||||||||
| Protein Structure |
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| UniProt Annotation | |||||||||
| Function | The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in rat bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation (By similarity). {ECO:0000250}. | ||||||||
| Subcellular Localization | Secreted. | ||||||||
| Disease Associations | |||||||||
| Tissue Specificity | |||||||||
| Comments | |||||||||
| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Protein Structure and Domains | |||||||||
| PDB ID | |||||||||
| InterPro |
IPR016179
Insulin-like IPR022341 Insulin-like growth factor I IPR022350 Insulin-like growth factor IPR022352 Insulin family |
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| PFAM |
PF00049
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| PRINTS |
PR02005
PR02002 PR00276 |
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| PIRSF | |||||||||
| SMART |
SM00078
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| TIGRFAMs | |||||||||
| Post-translational Modifications | |||||||||
| Modification | |||||||||
| Cross-References | |||||||||
| SwissProt | P07455 | ||||||||
| PhosphoSite | PhosphoSite- | ||||||||
| TrEMBL | Q9N1C1 | ||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | 281239 | ||||||||
| UniGene | |||||||||
| RefSeq | NP_001071296 | ||||||||
| HUGO | |||||||||
| OMIM | |||||||||
| CCDS | |||||||||
| HPRD | |||||||||
| IMGT | |||||||||
| EMBL | AF210385 AF210386 AF210387 AY277405 HQ324241 S76122 X15726 | ||||||||
| GenPept | AAD14209 AAF72409 AAP34700 AEA06507 CAA33746 | ||||||||