Version 5.4
Bos taurus Protein: IGF1
Summary
InnateDB Protein IDBP-689152.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IGF1
Protein Name Insulin-like growth factor I
Synonyms IGF-1; IGF-I;
Species Bos taurus
Ensembl Protein ENSBTAP00000055243
InnateDB Gene IDBG-637164 (IGF1)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.
Predicted by orthology
Total 17 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005158 insulin receptor binding
GO:0005159 insulin-like growth factor receptor binding
GO:0005178 integrin binding
GO:0005179 hormone activity
GO:0005515 protein binding
GO:0008083 growth factor activity
Biological Process
GO:0001775 cell activation
GO:0001932 regulation of protein phosphorylation
GO:0001974 blood vessel remodeling
GO:0007399 nervous system development
GO:0008284 positive regulation of cell proliferation
GO:0008285 negative regulation of cell proliferation
GO:0010001 glial cell differentiation
GO:0010613 positive regulation of cardiac muscle hypertrophy
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0014834 skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration
GO:0014896 muscle hypertrophy
GO:0014904 myotube cell development
GO:0014911 positive regulation of smooth muscle cell migration
GO:0021940 positive regulation of cerebellar granule cell precursor proliferation
GO:0030104 water homeostasis
GO:0030166 proteoglycan biosynthetic process
GO:0030324 lung development
GO:0030879 mammary gland development
GO:0031017 exocrine pancreas development
GO:0032878 regulation of establishment or maintenance of cell polarity
GO:0033160 positive regulation of protein import into nucleus, translocation
GO:0034392 negative regulation of smooth muscle cell apoptotic process
GO:0035264 multicellular organism growth
GO:0035630 bone mineralization involved in bone maturation
GO:0040014 regulation of multicellular organism growth
GO:0042104 positive regulation of activated T cell proliferation
GO:0042523 positive regulation of tyrosine phosphorylation of Stat5 protein
GO:0043066 negative regulation of apoptotic process
GO:0043388 positive regulation of DNA binding
GO:0043410 positive regulation of MAPK cascade
GO:0043568 positive regulation of insulin-like growth factor receptor signaling pathway
GO:0045445 myoblast differentiation
GO:0045669 positive regulation of osteoblast differentiation
GO:0045725 positive regulation of glycogen biosynthetic process
GO:0045821 positive regulation of glycolytic process
GO:0045840 positive regulation of mitosis
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0046326 positive regulation of glucose import
GO:0046579 positive regulation of Ras protein signal transduction
GO:0048009 insulin-like growth factor receptor signaling pathway
GO:0048015 phosphatidylinositol-mediated signaling
GO:0048146 positive regulation of fibroblast proliferation
GO:0048286 lung alveolus development
GO:0048468 cell development
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0048754 branching morphogenesis of an epithelial tube
GO:0048839 inner ear development
GO:0050650 chondroitin sulfate proteoglycan biosynthetic process
GO:0050679 positive regulation of epithelial cell proliferation
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0051246 regulation of protein metabolic process
GO:0051450 myoblast proliferation
GO:0051897 positive regulation of protein kinase B signaling
GO:0060426 lung vasculature development
GO:0060463 lung lobe morphogenesis
GO:0060509 Type I pneumocyte differentiation
GO:0060510 Type II pneumocyte differentiation
GO:0060527 prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis
GO:0060736 prostate gland growth
GO:0060740 prostate gland epithelium morphogenesis
GO:0060741 prostate gland stromal morphogenesis
GO:0060766 negative regulation of androgen receptor signaling pathway
GO:0070373 negative regulation of ERK1 and ERK2 cascade
GO:0070886 positive regulation of calcineurin-NFAT signaling cascade
GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand
GO:2000288 positive regulation of myoblast proliferation
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
Protein Structure and Domains
PDB ID
InterPro IPR016179 Insulin-like
IPR022341 Insulin-like growth factor I
IPR022350 Insulin-like growth factor
IPR022352 Insulin family
PFAM PF00049
PRINTS PR02005
PR02002
PR00276
PIRSF
SMART SM00078
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL Q7YSG5
UniProt Splice Variant
Entrez Gene 281239
UniGene
RefSeq XP_005206547
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AY277405 DAAA02013700 DAAA02013701 DAAA02013702 HQ324242 Y18831
GenPept AAP34700 AEA06508 CAC33820

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca