InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: POMC

Summary

InnateDB Protein

IDBP-689205.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

POMC

Protein Name

Pro-opiomelanocortinNPPMelanotropin gammaCorticotropinMelanotropin alphaCorticotropin-like intermediary peptideLipotropin betaLipotropin gammaMelanotropin betaBeta-endorphinMet-enkephalin

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000010386

InnateDB Gene

IDBG-637211 (POMC)

Protein Structure

UniProt Annotation

Function

ACTH stimulates the adrenal glands to release cortisol.MSH (melanocyte-stimulating hormone) increases the pigmentation of skin by increasing melanin production in melanocytes.Beta-endorphin and Met-enkephalin are endogenous opiates.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

ACTH and MSH are produced by the pituitary gland.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001664	G-protein coupled receptor binding
GO:0005102	receptor binding
GO:0005179	hormone activity
GO:0031781	type 3 melanocortin receptor binding
GO:0031782	type 4 melanocortin receptor binding
GO:0070996	type 1 melanocortin receptor binding

Biological Process

GO:0006091	generation of precursor metabolites and energy
GO:0007165	signal transduction
GO:0007218	neuropeptide signaling pathway
GO:0007267	cell-cell signaling
GO:0008217	regulation of blood pressure
GO:0032098	regulation of appetite
GO:0032720	negative regulation of tumor necrosis factor production
GO:0033059	cellular pigmentation
GO:0042593	glucose homeostasis
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0070873	regulation of glycogen metabolic process
GO:2000852	regulation of corticosterone secretion

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0005782	peroxisomal matrix
GO:0030141	secretory granule

Protein Structure and Domains

PDB ID

InterPro

IPR001941 Pro-opiomelanocortin/corticotropin, ACTH
IPR013531 Pro-opiomelanocortin/corticotropin, ACTH, central region
IPR013532 Opiodes neuropeptide
IPR013593 Pro-opiomelanocortin N-terminal

PFAM

PF00976
PF08035
PF08384

PRINTS

PR00383

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P01190