InnateDB Protein
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IDBP-689596.2
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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MARCH5
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Protein Name
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E3 ubiquitin-protein ligase MARCH5
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Synonyms
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Species
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Bos taurus
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Ensembl Protein
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ENSBTAP00000027942
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InnateDB Gene
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IDBG-637571 (MARCH5)
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Protein Structure
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Function |
Mitochondrial E3 ubiquitin-protein ligase that plays a crucial role in the control of mitochondrial morphology by acting as a positive regulator of mitochondrial fission. May play a role in the prevention of cell senescence acting as a regulator of mitochondrial quality control. Promotes ubiquitination of FIS1, DNM1L and MFN1 (By similarity). {ECO:0000250}.
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Subcellular Localization |
Mitochondrion outer membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
17 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR011016
Zinc finger, RING-CH-type
IPR018957
Zinc finger, C3HC4 RING-type
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PFAM |
PF12906
PF00097
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PRINTS |
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PIRSF |
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SMART |
SM00744
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TIGRFAMs |
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Modification |
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SwissProt |
Q3ZC24
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PhosphoSite |
PhosphoSite-
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TrEMBL |
F1MBH0
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UniProt Splice Variant |
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Entrez Gene |
540937
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UniGene |
Bt.64008
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RefSeq |
NP_001029887
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HUGO |
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OMIM |
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CCDS |
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HPRD |
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IMGT |
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EMBL |
BC102966
DAAA02058815
DAAA02058816
DAAA02058817
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GenPept |
AAI02967
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