Version 5.4
Bos taurus Protein: IDE
Summary
InnateDB Protein IDBP-689604.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IDE
Protein Name Insulin-degrading enzyme
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000026332
InnateDB Gene IDBG-637578 (IDE)
Protein Structure
UniProt Annotation
Function Plays a role in the cellular breakdown of insulin, IAPP, glucagon, bradykinin, kallidin and other peptides, and thereby plays a role in intercellular peptide signaling. Degrades amyloid formed by APP and IAPP (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}. Secreted {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Predicted by orthology
Total 11 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0001948 glycoprotein binding
GO:0003824 catalytic activity
GO:0004222 metalloendopeptidase activity
GO:0005102 receptor binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008233 peptidase activity
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
GO:0016787 hydrolase activity
GO:0042277 peptide binding
GO:0042803 protein homodimerization activity
GO:0043130 ubiquitin binding
GO:0043559 insulin binding
GO:0046872 metal ion binding
Biological Process
GO:0006508 proteolysis
GO:0008152 metabolic process
GO:0008340 determination of adult lifespan
GO:0010815 bradykinin catabolic process
GO:0010992 ubiquitin homeostasis
GO:0032461 positive regulation of protein oligomerization
GO:0050435 beta-amyloid metabolic process
GO:0051260 protein homooligomerization
GO:0051603 proteolysis involved in cellular protein catabolic process
GO:1901142 insulin metabolic process
GO:1901143 insulin catabolic process
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005777 peroxisome
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0009986 cell surface
GO:0016020 membrane
Protein Structure and Domains
PDB ID
InterPro IPR007863 Peptidase M16, C-terminal domain
IPR011249 Metalloenzyme, LuxS/M16 peptidase-like
IPR011765 Peptidase M16, N-terminal
PFAM PF05193
PF00675
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q24K02
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 523752
UniGene Bt.6675
RefSeq NP_001069317
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC114105
GenPept AAI14106

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca