Version 5.4
Bos taurus Protein: BMI1
Summary
InnateDB Protein IDBP-689632.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BMI1
Protein Name Polycomb complex protein BMI-1
Synonyms PCGF4;
Species Bos taurus
Ensembl Protein ENSBTAP00000020705
InnateDB Gene IDBG-637604 (BMI1)
Protein Structure
UniProt Annotation
Function Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. In the PRC1 complex, it is required to stimulate the E3 ubiquitin-protein ligase activity of RNF2/RING2 (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 81 interaction(s) predicted by orthology.
Predicted by orthology
Total 81 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003682 chromatin binding
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0043565 sequence-specific DNA binding
GO:0046872 metal ion binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001501 skeletal system development
GO:0001701 in utero embryonic development
GO:0006306 DNA methylation
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006959 humoral immune response
GO:0007420 brain development
GO:0016568 chromatin modification
GO:0016573 histone acetylation
GO:0016574 histone ubiquitination
GO:0021903 rostrocaudal neural tube patterning
GO:0030890 positive regulation of B cell proliferation
GO:0033092 positive regulation of immature T cell proliferation in thymus
GO:0048103 somatic stem cell division
GO:0048704 embryonic skeletal system morphogenesis
GO:0048706 embryonic skeletal system development
GO:0051443 positive regulation of ubiquitin-protein transferase activity
GO:2001234 negative regulation of apoptotic signaling pathway
Cellular Component
GO:0000151 ubiquitin ligase complex
GO:0000792 heterochromatin
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0016604 nuclear body
GO:0031519 PcG protein complex
Protein Structure and Domains
PDB ID
InterPro IPR001841 Zinc finger, RING-type
IPR018957 Zinc finger, C3HC4 RING-type
PFAM PF13639
PF14634
PF00097
PRINTS
PIRSF
SMART SM00184
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q32KX7
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 510666
UniGene Bt.89241
RefSeq NP_001033161
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC109871
GenPept AAI09872

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca