Version 5.4
Bos taurus Protein: PFN2
Summary
InnateDB Protein IDBP-689738.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PFN2
Protein Name Profilin-2
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000014805
InnateDB Gene IDBG-637713 (PFN2)
Protein Structure
UniProt Annotation
Function Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG.
Subcellular Localization Cytoplasm, cytoskeleton.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 40 interaction(s) predicted by orthology.
Predicted by orthology
Total 40 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000774 adenyl-nucleotide exchange factor activity
GO:0003779 actin binding
GO:0003785 actin monomer binding
GO:0005515 protein binding
GO:0005546 phosphatidylinositol-4,5-bisphosphate binding
Biological Process
GO:0010633 negative regulation of epithelial cell migration
GO:0030036 actin cytoskeleton organization
GO:0030837 negative regulation of actin filament polymerization
GO:0030838 positive regulation of actin filament polymerization
GO:0032233 positive regulation of actin filament bundle assembly
GO:0032781 positive regulation of ATPase activity
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0051496 positive regulation of stress fiber assembly
GO:1900028 negative regulation of ruffle assembly
GO:2000300 regulation of synaptic vesicle exocytosis
Cellular Component
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0043195 terminal bouton
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR005454 Profilin, chordates
IPR005455 Profilin
PFAM PF00235
PRINTS PR01639
PR00392
PR01640
PIRSF
SMART SM00392
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q09430
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 539034
UniGene Bt.97781
RefSeq NP_001121669
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC122616
GenPept AAI22617

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca