InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: CRYZ

Summary

InnateDB Protein

IDBP-689864.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CRYZ

Protein Name

Zeta-crystallin

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000041239

InnateDB Gene

IDBG-637826 (CRYZ)

Protein Structure

UniProt Annotation

Function

Interacts with (AU)-rich elements (ARE) in the 3'-UTR of target mRNA species and enhances their stability. NADPH binding interferes with mRNA binding (By similarity). Has minimal or no quinone reductase activity. Binds strongly to single-stranded DNA. {ECO:0000250, ECO:0000269PubMed:9154917}.

Subcellular Localization

Cytoplasm {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003723	RNA binding
GO:0003730	mRNA 3'-UTR binding
GO:0003960	NADPH:quinone reductase activity
GO:0008270	zinc ion binding
GO:0016491	oxidoreductase activity
GO:0016747	transferase activity, transferring acyl groups other than amino-acyl groups
GO:0050661	NADP binding
GO:0070402	NADPH binding

Biological Process

GO:0042178	xenobiotic catabolic process
GO:0051289	protein homotetramerization
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005737	cytoplasm
GO:0005794	Golgi apparatus
GO:0005829	cytosol
GO:0043231	intracellular membrane-bounded organelle
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR011032 GroES (chaperonin 10)-like
IPR013149 Alcohol dehydrogenase, C-terminal
IPR013154 Alcohol dehydrogenase GroES-like
IPR020843 Polyketide synthase, enoylreductase

PFAM

PF00107
PF08240

PRINTS

PIRSF

SMART

SM00829

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O97764