Version 5.4
Bos taurus Protein: GPR37L1
Summary
InnateDB Protein IDBP-689895.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GPR37L1
Protein Name Endothelin B receptor-like protein 2
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000019957
InnateDB Gene IDBG-637863 (GPR37L1)
Protein Structure
UniProt Annotation
Function Receptor for the neuroprotective and glioprotective factor prosaposin. Ligand binding induces endocytosis, followed by an ERK phosphorylation cascade (By similarity). {ECO:0000250}.
Subcellular Localization Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004871 signal transducer activity
GO:0004930 G-protein coupled receptor activity
GO:0005515 protein binding
Biological Process
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0021940 positive regulation of cerebellar granule cell precursor proliferation
GO:0045665 negative regulation of neuron differentiation
GO:0045879 negative regulation of smoothened signaling pathway
GO:0048712 negative regulation of astrocyte differentiation
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0043235 receptor complex
Protein Structure and Domains
PDB ID
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
IPR003909 G protein-coupled receptor 37 orphan
IPR017452 GPCR, rhodopsin-like, 7TM
PFAM PF00001
PRINTS PR00237
PR01421
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q17QD8
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 527572
UniGene Bt.41530
RefSeq NP_001069367
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC118418
GenPept AAI18419

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca